Biortus presents itself as a comprehensive early-stage preclinical drug discovery CRO that can significantly shorten the time it takes to bring a new drug candidate to clinical trials by managing your entire project from initial "hit identification" to "lead optimization".
Biortus experienced drug discovery team provides a variety of screening options, including target engagement and phenotypic screening. Identifying hit molecules is a primary objective of your project. Biortus has an extensive range of testing equipment and skilled personnel dedicated to assay development, covering biochemical, biophysical, and cell-based assays for hit identification and validation. You will gain early insights into structure-activity relationships (SAR) and mechanisms of action (MOA), empowering you to make informed go/no-go decisions. As your one-stop provider for high-throughput screening, we are committed to advancing your novel therapeutic discovery.
Hit Discovery
Lead generation





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Multiple libraries to chose
Lead-like
Covalent
Fragment
Molecular glue
DEL through collaboration
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Comprehensive HTS triage strategy for your target
Design,development,validation of primary screening assay
Design and develop secondary/counter/orthogonal assays
Screening condition and triage path recommendations
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Multiple formats
Biophysical assays
Biochemical assays
Cell-based assays
Label free
High Content Analysis
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Mature experiences on target analysis
Target degradation assays
Kinase panel assays
DUBs panel assays
GPCR panel assays
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Well equipped for QC of reagents, binding affinity test, and functional test in low, medium, and high through-put formats.
Biochemical Assays




Biochemical Assays
Cell-based Assays

Target specific platforms
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2
Kinase platform
A total of~300 kinases available
MSA (Caliper) assay ready for~300 targets
ADP-GLO assay ready for>100 targets
SPR assay ready for>60 targets
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3
Dubs platform
39 biologically active DUBs for Custom Assay Development and HTS
18 ready to use assay kits for HTS and validation
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4
GPCR platform
GPCR surface expression validation
GPCR signal transduction research
GPCR biased signaling
GPCR compound/ligand binding
GPCR pharmacological study