Service Capability
Cutting-Edge Instruments - Transmission Electron Microscopes
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Krios G4
Thermo Scientific Krios G4 Cryo Transmission Electron Microscope allows scientists to uncover the mysteries of life at the atomic level more easily, quickly, and reliably than ever before. As the smallest TEM in its class, the Krios G4 is built on a highly stable 300 kV TEM platform and features the industry-leading Autoloader automated sample loading system. It is ideally suited for automated applications such as Cryo-Electron Tomography (Cryo-ET), Single Particle Analysis (SPA), and Microcrystal Electron Diffraction (MicroED).
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Glacios
Glacios is developed based on the Tecnai F20. Equipped with a highly stable field emission gun (FEG), it significantly enhances the coherence and brightness of the illumination source. The system features revolutionary cryogenic technology, allowing up to 12 samples to be loaded at once, with continuous automatic maintenance of the samples at liquid nitrogen temperature. A high-speed digital camera (SmartCam) replaces the traditional fluorescent screen, enabling users to perform remote operations through an innovative digital interface. The high stability of the electron optical system and sample stage, combined with advanced digital control software, supports high-level automated operation. Glacios is an ideal choice for sample screening before transferring samples to the Krios for ultra-high-resolution data acquisition.
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Talos L120C
Thermo Scientific Talos L120C is a next-generation 120 kV imaging platform featuring a modular design and optimized optical stability, delivering exceptional ease of use, high efficiency, operational comfort, and a high proportion of uptime. With simple click-to-image operation, it is an ideal choice for entry-level cryoEM research. Additionally, it can efficiently perform tomography and Single Particle Analysis (SPA) sample screening, with optional addons such as Energy-Dispersive X-ray Spectroscopy (EDS) and Scanning Transmission Electron Microscopy (STEM) modules.
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TF20
FEI Tecnai TF20 is a 200 kV field-emission high-resolution TEM suitable for cryo single particle analysis (SPA) and semi-thick frozen cells or sections (up to 200 nm) for electron microscopy and electron tomography. The TF20 is equipped with a field emission gun (FEG) and a computer-controlled liquid nitrogen cryo-stage with a tilt range of +/-80 degrees. The microscope is fitted with a TIETZ F415MP 4k x 4k multi-port CCD camera, featuring 4 readout ports and a pixel size of 15 µm. Images can also be recorded using a conventional film camera. The TF20 TEM, part of the FEI Tecnai G2 series, is well-suited for cryo electron microscopy and cryo electron tomography.
Research Team
Biortus has a dedicated team specializing in cryo-EM structure determination, with a current team size of over 60 members, including more than 10 Ph.D.s (several of whom are returning overseas Ph.D.s) and over 40 masters. The team is highly passionate about structural biology, particularly in the field of cryo-EM.
Our staff have extensive experience in providing CRO services for early-stage drug discovery. Our clients include over 300 organizations worldwide, ranging from leading pharmaceutical companies and biotech firms to academic research institutions. With deep technical expertise and efficient service capabilities, our performance far exceeds industry averages, earning us widespread trust and recognition from our clients.
