Instrumentations
Compound screening against a drug target whether by high-throughput screening or fragment screening is a vital step in early stage drug discovery. Biortus has an extensive collection of plate readers (detecting UV/light absorbance, fluorescence, luminescence, and scintillation) that allows development of many kinds of biochemical assays including cell-based assays. Coupled with our automated liquid handling machines, we could perform various high-throughput screening (HTS) for our clients. In addition, Biortus currently holds two other specialised screening technologies, Mobility Shift Assays (Caliper EZ Reader II, great for monitoring enzyme reactions) and Surface Plasmon Resonance (SPR, Biacore S200) for fragment screening. Below is a non-exhaustive list of assays performed in Biortus:
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Assay Description |
Mode of Detection |
Instrument |
Feature Highlights |
|
Kinase Assays |
Mobility Shift and Fluorescence |
Caliper EZ Reader II |
|
|
ADP-Glo Assay |
Luminescence |
TECAN Infinite F200 Pro/M1000
Perkin Elmer Envision 2104 |
|
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LANCE TR-FRET |
Time-Resolved Fluorescence |
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|
Fluorescence Polarization Assay |
Fluorescence Polarization |
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CellTiter-Glo® Luminescent Cell Viability Assay |
Cell-Based Luminescence |
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|
MTT Cell Proliferation and Cytotoxicity Assay |
Cell-Based Absorbance |
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|
AlphaScreen |
Chemical Energy Transfer and Fluorescence |
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|
Scintillation Proximity Assay |
Radiometric |
Perkin Elmer TopCount NTX HTS |
|
|
Surface Plasmon Resonance |
Light Absorption Shift |
Biacore S200
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