Recombinant protein
E3 Ligase Family
Protein degradation is a regulated, multistep process. Ubiquitin is loaded onto E1-activating enzymes in an ATP-dependent manner and then transferred to E2-binding enzymes. The same E2 can bind to many E3 ligases, which in turn can ubiquitinate multiple target substrate proteins. E3 ligases bind specific substrate proteins based on substrate degron motifs.
E3 ubiquitin ligases play crucial roles in eukaryotic biology by promoting protein ubiquitination and degradation. Human genome encodes over 600 E3 ubiquitin ligases which could function in distinct cellular contexts, respond to different cellular signals, and process diverse protein targets. In recent years, various E3 ligases became pharmacological targets for developing drugs. Two novel strategies, proteolysis-targeting chimeras (PROTAC) and molecular glue make E3 ligase protein production necessary for structure-based drug design.
The Biortus Protein Catalogue currently offers over 100 of E3 ubiquitin ligases expressed in multiple expression systems, with several structurally resolved and assay developments ready.
|
Catalog No. |
Organism |
Expression system |
Tag |
Sequence |
|
Homo sapiens |
E. coli |
His |
S2-K592 |
|
|
Homo sapiens |
E. coli |
His |
T2-A490 |
|
|
Homo sapiens |
E. coli |
GST |
G120-I190 |
|
|
Homo sapiens |
E. coli |
GST |
A2-Q228 |
|
|
Homo sapiens |
E. coli |
His |
L2-F882 |
|
|
Homo sapiens |
Insect cell |
His/Strep |
A2-T344 |
|
|
Homo sapiens |
E. coli |
GST |
Y120-P260 |
|
|
Homo sapiens |
Insect cell |
His/Strep |
M1-S618 |
|
|
Homo sapiens |
E. coli |
His |
S2-E748 |
|
|
Homo sapiens |
E. coli |
His |
A2-E870 |
|
|
Homo sapiens |
Insect cell |
His/Strep |
S2-T505 |
|
|
Homo sapiens |
E. coli |
His |
K2-Y303 |
|
|
Homo sapiens |
Insect cell |
His/Strep |
A2-A780 |
|
|
Homo sapiens |
Insect cell |
His |
G2-L216 |
|
|
Homo sapiens |
E. coli |
His |
S17-N111 |
|
|
Homo sapiens |
E. coli |
His |
S2-D474 |
|
|
Homo sapiens |
E. coli |
His |
A2-D975 |
|
|
Homo sapiens |
Insect cell |
His/Strep |
A2-L600 |
See All Recombinant Proteins >>>
For custom E3 ligase protein generation, please see Protein Generation or contact info@biortus.bio.
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