BP08867-01A-Biortus Biosciences Co. Ltd.

BP08867-01A

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Family ：

E3 ubiquitin-protein ligase

Catalog No. ：

BP08867-01A

Protein ：

BRAP

UniProt ：

Q7Z569

Organism ：

Homo sapiens

Expression system ：

E. coli

Tag ：

His

Sequence ：

S2-K592

Inquiry ：

是

Symbol/Gene Name: BRAP

Alias: BRCA1-associated protein,BRAP2,Impedes mitogenic signal propagation,IMP,RING finger protein 52,RING-type E3 ubiquitin transferase BRAP2,Renal carcinoma antigen NY-REN-63

Uniprot: Q7Z569

Background: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

Construct: 6His-TEV-(GG)-BRAP(S2-K592 end)

Expression Host: E. coli

Purity: 85%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 5% glycerol, 1 mM DTT.

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Recombinant protein

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