BP11714-02A-Biortus Biosciences Co. Ltd.

BP11714-02A

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Family ：

E3 ubiquitin-protein ligase

Catalog No. ：

BP11714-02A

Protein ：

RNF4

UniProt ：

P78317

Organism ：

Homo sapiens

Expression system ：

E. coli

Tag ：

GST

Sequence ：

G120-I190

Inquiry ：

是

Symbol/Gene Name: RNF4

Alias: E3 ubiquitin-protein ligase RNF4,RING finger protein 4,RING-type E3 ubiquitin transferase RNF4,Small nuclear ring finger protein,Protein SNURF

Uniprot: P78317

Background: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

Construct: GST-TEV-G-RNF4(G120-I190 end)

Expression Host: E. coli

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Recombinant protein

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