BP08523-01A-Biortus Biosciences Co. Ltd.

BP08523-01A

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Family ：

E3 ubiquitin-protein ligase

Catalog No. ：

BP08523-01A

Protein ：

WWP2

UniProt ：

O00308

Organism ：

Homo sapiens

Expression system ：

E. coli

Tag ：

His

Sequence ：

A2-E870

Inquiry ：

是

Symbol/Gene Name: WWP2

Alias: NEDD4-like E3 ubiquitin-protein ligase WWP2,Atrophin-1-interacting protein 2,AIP2,HECT-type E3 ubiquitin transferase WWP2,WW domain-containing protein 2

Uniprot: O00308

Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.

Construct: 6His-TEV-(GG)-WWP2(A2-E870 end)

Expression Host: E. coli

Purity: 80%

Formulation:

Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 5% glycerol, 1 mM DTT.

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Recombinant protein

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