BP13911-13A-Biortus Biosciences Co. Ltd.

BP13911-13A

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Family ：

E3 ubiquitin-protein ligase

Catalog No. ：

BP13911-13A

Protein ：

CUL5

UniProt ：

Q93034

Organism ：

Homo sapiens

Expression system ：

Insect cell

Tag ：

His/Strep

Sequence ：

A2-A780

Inquiry ：

是

Symbol/Gene Name: CUL5

Alias: Cullin-5,CUL-5,Vasopressin-activated calcium-mobilizing receptor 1,VACM-1

Uniprot: Q93034

Background: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11384984, PubMed:15601820). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:11384984, PubMed:15601820). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component (PubMed:11384984, PubMed:15601820). ECS(SOCS1) seems to direct ubiquitination of JAK2 (PubMed:11384984). ECS(KLHDC1) complex is part of the DesCEND (destruction via C-end degrons) pathway and mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine (PubMed:32200094). May form a cell surface vasopressin receptor (PubMed:9037604).

Construct: 8His-StrepII-TEV-(GG)-CUL5(A2-A780 end)

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Recombinant protein

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