Working Collaboratively, Growing Together
Biortus
Working Collaboratively, Growing Together
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Crystallography, Cryo-EM, and MicroED
Structural Biology
Crystallography, Cryo-EM, and MicroED
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20000+ Plasmids!
Biortus
20000+ Plasmids!
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6000+ Drug Targets!
Biortus
6000+ Drug Targets!
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300+ Membrane Proteins!
Biortus
300+ Membrane Proteins!
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One-Stop Solution 
From Gene Synthesis 
To Cryo-EM Structure

Biortus is a leading world-class contract research organization that provides a one-stop service of gene synthesis to structure determination. Since 2009, Biortus has partnered worldwide with numerous research institutions, pharmaceutical and biotechnology companies - consistently providing high-quality custom proteins for all stages of biomedical research.

 

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Biortus

What we do ?

To help our clients achieve their drug discovery goals, we have established three world-class research platforms. These are Protein Production, Structural Biology (Crystallography, Cryo-EM, and MicroED), and In Vitro Assays and Screening. 

  • Protein Production

    Every year, the Biortus protein production team successfully delivers over 5000 batches customized recombinant proteins, mostly drug target proteins, to our clients, including enzymes, kinases, transcription factors, immunity related proteins, GPCRs, Transporters, Solute Carrier Family members (SLCs), E3 ligases, epigenetic proteins and others.

    Plasmid Construction Expression Systems Purification Procedures Quality Control

  • Assays

    Compound screening against a drug target is a vital step in early stage drug discovery. Biortus has an extensive collection of testing equipment that allows development of many kinds of biochemical assays, biophysical assays, and cell-based assays.

    Instrumentations Established Assays Fragment Libraries

  • Structural Biology

    Compound screening against a drug target is a vital step in early stage drug discovery. Biortus has an extensive collection of testing equipment that allows development of many kinds of biochemical assays, biophysical assays, and cell-based assays.

    Crystallography Cryo-EM MicroED Computational Structural Biology

Biortus Protein Catalogue

20000+ Plasmids!
6000+ Drug Targets!
300+ Membrane Proteins!

Biortus now provides an off-the-shelf Protein Catalogue through our subsidiary, Biortus USA, to better serve the global life science industry at the same high quality. Many of these proteins have been crystallized and/or structurally elucidated using our in-house X-ray and Cryo-EM facilities. The Biortus Protein Catalogue currently comprises of over 1,700 independent drug targets, consisting of Membrane Proteins, Kinases, ubiquitin-proteasome enzymes (DUBS and E3 Ligases), CDKs (cyclin and cyclin dependent kinases) and more, covering a wide range of therapeutic areas.

 

CDK Family

CDK Family

Continuous proliferation is an important hallmark of tumor cells, blocking the tumor cell cycle has become an important means to control tumor development.

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DUBs Family

DUBs Family

Protein ubiqutinylation, the covalent post-translational addition of ubiquitin, and deubiquitinylation is a dynamic and reversible process, orchestrated by the concerted effort of the ubiquitin ligase and deubiquitin peptidase (DUBs) families. Ubiquitinylation is critical in regulating protein degradation, protein-protein interactions, cellular localization, and enzymatic activity - dictating numerous important cellular processes.

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E3 Ligase Family

E3 Ligase Family

Protein degradation is a regulated, multistep process. Ubiquitin is loaded onto E1-activating enzymes in an ATP-dependent manner and then transferred to E2-binding enzymes. The same E2 can bind to many E3 ligases, which in turn can ubiquitinate multiple target substrate proteins. E3 ligases bind specific substrate proteins based on substrate degron motifs.

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COVID-19 Proteins

COVID-19 Proteins

COVID-19 is one of most severe and contagious virus in human history. Since the outbreak of COVID-19 in 2019, more than 500 million people were infected and it led to over 6 million deaths.

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Membrane Protein

Membrane Protein

Membrane proteins play an important role in cells, they are involved in cell-to-cell, cell-to-matrix interactions, cell formation, and transmembrane transport of various ions, metabolites and proteins.

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Ras Family

Ras Family

The Ras oncogenes were the first human oncogenes discovered in human tumors, and it belongs to the small GTPase superfamily.

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Biortus: Your Preferred Partner

Biortus’s core capabilities include target protein production, biochemical / biophysical / cellular assay development, compound screening and characterization, X-ray crystallography, cryo-EM for protein structure determination (SPA), and MicroED for small molecule crystal form and structure characterization. Biortus’s service is highly recognized by clients with co-authorship in more than 10 publications in prestigious journals including Science, Cell, Cell Research, Nature Communications, and JACS etc.

Biortus

Company History

Biortus Biosciences Science Co., Ltd was founded in 2009.

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Biortus

Our Publications

With our wide-range research capabilities, strong relevant expertise...

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News

Biortus one-stop service supports the research and development of new drugs for China Innovation Center of Roche (CICoR), published in Nature Communications

On April 11, 2024, Nature Communications published online an article of China Innovation Center of Roche (CICoR) in collaboration with Biortus, introducing the cryo-EM structure of the dimeric human parainfluenza virus type 3 (hPIV3) L-P complex.

Jun 14,2024

Biortus Announces Strategic Collaboration with Schrödinger

Today, Biortus Biosciences Co. Ltd. (“Biortus”) announced a multi-year partnership with Schrodinger, whose physics-based computational platform is transforming the way therapeutics and materials are discovered

Mar 01,2024

Go BIG! - Purification and Structural Determination of RyR1, 2.3MDa membrane protein

With our state-of-the-art CryoEM facility and gene-to-structure pipeline, Biortus’s experienced team has solved a 2.8 Å CryoEM structure of RyR1, the largest known ion channel at 2.3 MDa.

Feb 17,2023

Biortus Delivering hERG Protein and Cryo-EM Structures

As part of the drug safety assessment practice, ion channels are one of the key family proteins under tight scrutiny with almost every drug candidate. Unfortunately, as of now the effect of drug candi

Apr 26,2022

Biortus Delivering ABCB10 Protein and Cryo-EM Structures

A member of ATP-binding cassette (ABC) transporter family located in the inner membrane of mitochondria, ABCB10 in the liver functions as a transporter of liver biliverdin, the reduction product of bilirubin (Fig. 1).

Apr 26,2022

Installed Krios G4 Boosts Productivity at Biortus CryoEM Center

Reporting from Wuxi, the long anticipated Titan Krios G4, the first of its kind in China, is now installed and operational at the Biortus CryoEM Center.

May 03,2021

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