BP12849-01A-Biortus Biosciences Co. Ltd.

BP12849-01A

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Family ：

DUBs

Catalog No. ：

BP12849-01A

Protein ：

OTUD2

UniProt ：

Q5VVQ6

Organism ：

Homo sapiens

Expression system ：

E. coli

Tag ：

His

Sequence ：

F2-V348

Inquiry ：

是

Symbol/Gene Name: YOD1

Alias: Ubiquitin thioesterase OTU1,DUBA-8,HIV-1-induced protease 7,HIN-7,HsHIN7,OTU domain-containing protein 2

Uniprot: Q5VVQ6

Background: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation (PubMed:27753622).

Construct: 6His-TEV-GG-OTUD2(F2-V348 end)

Expression Host: E. coli

Purity: 80%

Formulation: 20mM Tris-HCl (pH 8.0), 150mM NaCl, 10% glycerol

Supplied as sterile.

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Recombinant protein

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