BP12389-01A-Biortus Biosciences Co. Ltd.

BP12389-01A

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Family ：

DUBs

Catalog No. ：

BP12389-01A

Protein ：

AMSHLP

UniProt ：

Q96FJ0

Organism ：

Homo sapiens

Expression system ：

E. coli

Tag ：

His

Sequence ：

D2-R436

Inquiry ：

是

Symbol/Gene Name: STAMBP

Alias: STAM-binding protein,Associated molecule with the SH3 domain of STAM,Endosome-associated ubiquitin isopeptidase

Uniprot: O95630

Background: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.

Construct: 6His-TEV-GG-AMSH(S2-R424 end)

Expression Host: E. coli

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Recombinant protein

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