Recombinant protein
COVID-19 Proteins
COVID-19 is one of most severe and contagious virus in human history. Since the outbreak of COVID-19 in 2019, more than 500 million people were infected and it led to over 6 million deaths. Its respiratory infections, long latency period, asymptomatic and prone to mutation properties make it the hardest tractable viruses in recent decades. Based on its strong scientific capacities, Biortus had heavily involved in COVID-19 pathological and drug development studies from the very beginning. Biortus Protein Production Department produced the RdRp enzyme, and Assay & Screening Department studied the inhibitory mechanism of remdesivir developed by Gilead, as shown in figure 1. More recently, Biortus CryoEM Department studied RdRp interaction with compound AT-520, and identified multiple binding sites. The novel discovery suggests that RdRp inhibitor could play more roles than RNA chain termination, figure 2.
|
Figure 1. Remdesivir inhibitor effect on RdRp. from W. Yin et al., Science (2020) |
Figure 2. Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527, from Ashleigh et al., BioRxiv (2021) |
The Biortus Protein Catalogue currently offers all COVID-19 component proteins, with Cryo-EM structurally resolved and specific in-house biochemical assays ready.
|
Catalog No. |
Organism |
Expression system |
Tag |
Sequence |
|
Homo sapiens |
Insect cell |
His |
M1-S740 |
|
|
SARS-CoV-2 |
E. coli |
His |
H13-G128 |
|
|
SARS-CoV-2 |
E. coli |
His |
A1-Q139 |
|
|
SARS-CoV-2 |
E. coli |
GST |
A1-Q527 |
|
|
SARS-CoV-2 |
E. coli |
His |
S1-N298 |
|
|
SARS-CoV-2 |
E. coli |
His |
A181-G818 |
|
|
SARS-CoV-2 |
E. coli |
His |
E1-T312 |
|
|
SARS-CoV-2 |
E. coli |
GST |
N405-Q500 |
|
|
SARS-CoV-2 |
E. coli |
His |
S1-Q306 |
|
|
SARS-CoV-2 |
E. coli |
His |
S3831-Q3913 |
|
|
SARS-CoV-2 |
E. coli |
His/Flag |
A1-Q198 |
|
|
SARS-CoV-2 |
E. coli |
His |
N4118-Q4230 |
|
|
SARS-CoV-2 |
Insect cell |
His/Flag |
M1-A419 |
|
|
SARS-CoV-2 |
Insect cell |
His |
R306-G531 |
|
|
SARS-CoV-2 |
Insect cell |
His/Strep |
S1-Q932 |
|
|
SARS-CoV-2 |
Mammalian cell |
His |
M1-Q1208, K986P, V987P |
|
|
2019-nCoV |
E. coli |
His |
E1-T312 |
See All Recombinant Proteins >>>
For custom COVID-19 protein generation, please see Protein Generation or contact info@biortus.bio.
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