DUBs Family-Biortus Biosciences Co. Ltd.

Recombinant protein

DUBs Family

Protein ubiqutinylation, the covalent post-translational addition of ubiquitin, and deubiquitinylation is a dynamic and reversible process, orchestrated by the concerted effort of the ubiquitin ligase and deubiquitin peptidase (DUBs) families. Ubiquitinylation is critical in regulating protein degradation, protein-protein interactions, cellular localization, and enzymatic activity - dictating numerous important cellular processes.

DUBs are a family of peptidases responsible for cleaving or editing these ubiquitin chains, thereby rescuing proteins from proteosomal degradation and restoring intracellular signaling cascades. With 6 distinct classes of DUBs, over 100 diverse family members total, categorized by their well characterized catalytic domains, DUBs serve as attractive therapeutic targets. Dysregulation of DUB activity has been implicated in a variety of human disease states, most commonly cancer. Recent advancements have contributed to the renewed interest in the therapeutic potential of pharmacologically modulating DUBs.

Figure 1. DUB and Setrin/SUMO specific protease(SENP) phylogenetic tree. All 6 classes of DUBs are represented here: ubiquitin-specific proteases (USP), ubiquitin carboxy-terminal hydrolases (UCH), Machado-Josephin domain-containing proteases (MJD), ovarian tumor proteases (OTU), motif-interacting with ubiquitin-containing novel DUB family (MINDY) and JAB1, MPN, MOV34 family (JAMM).
from Harrigan, J. et al, Nature Reviews 2016.

The Biortus Protein Catalogue currently offers 67 DUBs expressed in multiple expression systems, with 3 structurally resolved and specific in-house biochemical assays for all 6 classes of DUBs readily available.

Catalog No.	Organism	Expression system	Tag	Sequence
BP12389-01A	Homo sapiens	E. coli	His	D2-R436
BP12432-14A	Homo sapiens	Insect cell	His/Flag	D2-K355
BP12774-01A	Homo sapiens	E. coli	His	S2-D188
BP13015-01A	Homo sapiens	E. coli	His	Q2-S481
BP12849-01A	Homo sapiens	E. coli	His	F2-V348
BP12839-01A	Homo sapiens	E. coli	His	Q2-A223
BP12423-01A	Homo sapiens	Insect cell	His	P2-K324
BP12769-00A	Homo sapiens	E. coli	No tag	D2-K212
BP12837-01A	Homo sapiens	E. coli	His	T2-K329

See All Recombinant Proteins >>>
For custom DUBs generation, please see Protein Generation or contact info@biortus.bio.

ABOUT US

Company Profile
Company History
Our Publication
News
Career

SERVICE

Protein Production
Assay
Structural Biology

PRODUCTS

Recombinant protein

Structure Gallery

Telephone：+86 0510-86130005

Adresse：A5, 6 Dongsheng W. Rd., Jiangyin, Jiangsu, China

E-mail：info@biortus.bio

NEWS FEEDS