Recombinant protein
Ras Family
The Ras oncogenes were the first human oncogenes discovered in human tumors, and it belongs to the small GTPase superfamily. The Ras proteins play an important role in the regulation of cell proliferation.
Activation of receptor tyrosine kinases, such as members of the epidermal growth factor receptor (EGFR) family, promotes the exchange of GDP for GTP in RAS, thereby activating RAS. Inhibition of EGFR can reduce this activation. Inhibition of SOS or SHP2 decreases the rate of GDP–GTP exchange and reduces the GTP-bound RAS population. Mutant RAS proteins accumulate in the GTP-bound state. A number of approaches have been developed to directly inhibit RAS, including covalent allele-specific inhibitors that bind to KRAS-G12C. GTP-bound RAS activates downstream signalling by binding to the RAS-binding domain of effector proteins, such as RAF and p110, to activate the MAPK and PI3K signalling cascades, respectively. Both the MAPK and PI3K signalling cascades can be inhibited at each kinase tier.
Moore, A. R. , et al. "RAS-targeted therapies: is the undruggable drugged?." Nature Reviews Drug Discovery 13 Suppl.(2020).
The Biortus Protein Catalogue currently offers multiple modifications (biotinylated, GDP-loaded, GTP-loaded, GMPPNP-loaded) for several Ras mutations expressed in E. coli expression systems, with all the structurally resolved.
|
Catalog No. |
Organism |
Expression system |
Tag |
Sequence |
|
Homo sapiens |
E. coli |
GST |
T2-K169, G12A |
|
|
Homo sapiens |
E. coli |
GST |
T2-K169, G12R |
|
|
Homo sapiens |
E. coli |
GST |
T2-K169, G12C |
|
|
Homo sapiens |
E. coli |
GST |
T2-K169, G12V |
|
|
Homo sapiens |
E. coli |
GST |
T2-K169, G12S |
|
|
Homo sapiens |
E. coli |
GST |
T2-K169, G12D |
|
|
Homo sapiens |
E. coli |
GST |
T2-K169, G13D |
|
|
Homo sapiens |
E. coli |
biotinylated |
M1-M188 end, Q61K |
|
|
Homo sapiens |
E. coli |
biotinylated |
M1-M188 end, Q61R |
|
|
Homo sapiens |
E. coli |
GST |
T2-K169 |
|
|
Homo sapiens |
E. coli |
GST |
T2-K169, Q61L |
|
|
Homo sapiens |
E. coli |
GST |
T2-K169, Q61H |
|
|
Homo sapiens |
E. coli |
biotinylated |
M1-K169, G12D |
|
|
Homo sapiens |
E. coli |
biotinylated |
M1-K169, G13D |
|
|
Homo sapiens |
E. coli |
biotinylated |
M1-K169, Q61K |
|
|
Homo sapiens |
E. coli |
biotinylated |
M1-K169, Q61R |
|
|
Homo sapiens |
E. coli |
GST |
M1-R169 |
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For custom Ras generation, please see Protein Generation or contact info@biortus.bio.
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