Structural Biology
Protein Design
Protein design facilitates the understanding of protein functions by rationally designing new protein molecules, optimizing their activity and behavior. According to different design purposes, protein design can be divided into protein structure design and protein function design. Protein structure design is divided into two types: de novo protein structure design and protein structure modification. A reasonable protein design method performs protein sequence prediction and folds it into a specific structure. These predicted sequences can then be experimentally verified by methods such as peptide synthesis, site-directed mutagenesis, or artificial gene synthesis. The protein design divided into enzyme design, affinity design, specificity design, membrane protein design etc. Protein modification could improve the thermal stability of the protein through modification of the protein core or protein surface, implement the miniaturization of proteins through structural domain modification, and implement the miniaturization of enzymes through the redesign of the protein topology.
David Baker, professor of the University of Washington, is a leading figure in protein design field. As the developer of the computational modeling and protein structure analysis software Rosetta, he designed a series of proteins with important physiological significance, including IL2 and IL15 receptor agonists, heterologous interacting proteins, multiple transmembrane proteins, protein fibers, etc. Biortus computational structure team is committed to apply and learn the advanced protein design concepts and methods to provide customers with high-quality solutions.
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