BP13226-41A

Family :

GPCR

Catalog No. :

BP13226-41A

Protein :

5HT1B

UniProt :

P28222

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

Flag,His

Sequence :

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Symbol/Gene Name:  HTR1B

Alias:  5-hydroxytryptamine receptor 1B,5-HT-1B,5-HT1B,S12,Serotonin 1D beta receptor,5-HT-1D-beta,Serotonin receptor 1B

Uniprot: P28222

Background: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

Construct: Flag-10His-TEV-5HT1B(N32-I239) (L138W)-BRIL-5HT1B(A306-S390 end)

Expression Host: Insect cell

Purity: 90%

Formulation:

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

 

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