BP12351-01A

Family :

Protease and Enzyme

Catalog No. :

BP12351-01A

Protein :

NUDT1

UniProt :

P36639

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

His

Sequence :

Y2-V197

Inquiry :

Symbol/Gene Name:  NUDT1

Alias:  Oxidized purine nucleoside triphosphate hydrolase,2-hydroxy-dATP diphosphatase,7,8-dihydro-8-oxoguanine triphosphatase,8-oxo-dGTPase,Methylated purine nucleoside triphosphate hydrolase,Nucleoside diphosphate-linked moiety X motif 1,Nudix motif 1

Uniprot: P36639

Background: Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:8226881, PubMed:7713500, PubMed:10608900, PubMed:12857738, PubMed:22556419, PubMed:26238318, PubMed:24695224, PubMed: 24695225, PubMed:28679043). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (PubMed:10373420). Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:10373420, PubMed:11139615). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed: 24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205). Through this antimutagenic activity protects cells from oxidative stress (PubMed:8226881, PubMed:7713500, PubMed:10608900, PubMed:12857738, PubMed:24695224, PubMed:24695225, PubMed:30304478, PubMed:32144205).

Construct: 6His-TEV-GG-NUDT1(human) (Y2-V197 end)

Expression Host: E. coli

Purity:  90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol 

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

 

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