BP05741-01A

Family :

Epigenetic

Catalog No. :

BP05741-01A

Protein :

KDM6B

UniProt :

O15054

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

His

Sequence :

D1141-L1636

Inquiry :

Symbol/Gene Name:  KDM6B

Alias:  Lysine-specific demethylase 6B,JmjC domain-containing protein 3,Jumonji domain-containing protein 3,Lysine demethylase 6B,[histone H3]-trimethyl-L-lysine(27) demethylase 6B

Uniprot: O15054

Background: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity).

Construct: 8His-TEV-KDM6B(D1141-L1636)

Expression Host: Insect cell

Purity: 90%

Formulation: 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

 

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