BP05797-00A

Family :

Kinase

Catalog No. :

BP05797-00A

Protein :

DYRK1A

UniProt :

Q13627

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

No tag

Sequence :

S127-E485

Inquiry :

Product Information

Symbol/Gene Name:  DYRK1A

Alias:  Dual specificity tyrosine-phosphorylation-regulated kinase 1A,Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,MNBH,hMNB

Uniprot: Q13627

Background: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an important role in double-strand breaks (DSBs) repair following DNA damage (PubMed:31024071). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (PubMed:30773093). May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity).

Construct: DYRK1A(S127-E485)

Expression Host: E. coli

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

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