BP13813-00A

Family :

Others

Catalog No. :

BP13813-00A

Protein :

Diablo

UniProt :

Q9NR28

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

No tag

Sequence :

A56-D239

Inquiry :

Product Information

Symbol/Gene Name:  DIABLO

Alias:  Diablo IAP-binding mitochondrial protein,Diablo homolog, mitochondrial,Direct IAP-binding protein with low pI,Second mitochondria-derived activator of caspase,Smac

Uniprot: Q9NR28

Background: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

Construct: GG-Diablo(A56-D239 end)

Expression Host: E. coli

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

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