BP08086-01A

Family :

Protease and Enzyme

Catalog No. :

BP08086-01A

Protein :

NADPH-dependent aldose reductase

UniProt :

P38715

Organism :

Saccharomyces cerevisiae

Expression system :

E. coli

Tag :

His

Sequence :

M1-A327

Inquiry :

Product Information

Symbol/Gene Name:  GRE3

Alias:  NADPH-dependent aldose reductase GRE3,AR,Genes de respuesta a estres protein 3,NADPH-dependent aldo-keto reductase GRE3,Xylose reductase

Uniprot: P38715

Background: Aldose reductase with a broad substrate specificity. Reduces the cytotoxic compound methylglyoxal (MG) to acetol and (R)-lactaldehyde under stress conditions. MG is synthesized via a bypath of glycolysis from dihydroxyacetone phosphate and is believed to play a role in cell cycle regulation and stress adaptation (PubMed:11525399). In pentose-fermenting yeasts, aldose reductase catalyzes the reduction of xylose into xylitol. The purified enzyme catalyzes this reaction, but the inability of S.cerevisiae to grow on xylose as sole carbon source indicates that the physiological function is more likely methylglyoxal reduction (Probable) (PubMed:11722921).

Construct: 6His-TEV-GG-NADPH-dependent aldose reductase(M1-A327 end)

Expression Host: E. coli

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

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