BP10297-02A

Family :

Kinase

Catalog No. :

BP10297-02A

Protein :

CaMK4

UniProt :

Q16566

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

GST

Sequence :

L2-Y473

Inquiry :

Product Information

Symbol/Gene Name:  CAMK4

Alias:  Calcium/calmodulin-dependent protein kinase type IV,CaMK IV,CaM kinase-GR

Uniprot: Q16566

Background: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

Construct: GST-TEV-GG-CaMK4(L2-Y473 end)

Expression Host: Insect cell

Purity: 80%

Formulation: 50 mM Tris-HCl (pH 7.5), 150 mM NaCl, 5% glycerol, 5mM DTT, 0.1M Trehalose

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

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