BP09992-02A

Family :

Kinase

Catalog No. :

BP09992-02A

Protein :

AURC

UniProt :

Q9UQB9

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

GST

Sequence :

S2-S309

Inquiry :

Product Information

Symbol/Gene Name:  AURKC

Alias:  Aurora kinase C,Aurora 3,Aurora/IPL1-related kinase 3,ARK-3,Aurora-related kinase 3,Aurora/IPL1/Eg2 protein 2,Serine/threonine-protein kinase 13,Serine/threonine-protein kinase aurora-C

Uniprot: Q9UQB9

Background: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

Construct: GST-TEV-GG-AURC(S2-S309 end)

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

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